|
KMID : 1002320040020010076
|
|
Journal of Animal Medical Science
2004 Volume.2 No. 1 p.76 ~ p.85
|
|
|
Treatement for Growth Hormone Response Dermatopathy with Human Growth Hormone and Mitotane in Pomeranians
|
|
SHIO Daiichi
SEKI Masayuki
KUMAN Michiyo
KOUNOSE Masami
ARAI Nobuaki
FUJIKAWA Kazuhito
YAMAGATA Kiroyuki
TANADA Atsushi
NAGAI Tatsuhiro
NAKAGAWA Youji
|
|
|
Abstract
|
|
|
Two castrated male Pomeranians, having bilateral, symmetrical alopecia and hyperpigmentation, were diagnosed as growth hormone (GH) responsive dermatopathy by ACTH stimulation test, low dose dexamethasone suppression test and GH reactive test (xylazine response test). They were teated twice a week for six weeks by injecting 0.1 IU/㎏ of GH preparation into the muscle. Case 1 dog showed a significant recovery, but relapse occured after one year. Case 2 dog showed a low reactivity to it. Therefore both of them were treated with mitotane (op’-DDD, Lysodren®). Case 1 dog recovered and case 2 dog improved in coat.
It is reported that Pomeranians hereditatily lacks in a specific hydroxylase activity and have potential hyperpogesteronemia and hyper-androgenemia. It is suggested that Pomeranians overproduce the adrenal cortex without showing hypercortisonemia. This result, that mitotane, as a seletive disintegrator of adrenal cortex, is efficacious against GH responsive dermatosis and give another support to the view that the disease is related with the function of adrenal cortex.
|
|
|
KEYWORD
|
|
|
growth hormone responsive dermatopathy, mitotane, Pomeranian
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|